Iodoethane → HCID 11630692, compound

HRID 2263487Notes

Reaction equation

HRID 2263487 reaction equation
[F:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:26][CH3:27]>C(#N)C>[CH2:26]([N:16]1[CH2:15][CH2:14][CH:13]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([O:8][C:9]([F:10])([F:11])[F:12])[C:2]=2[F:1])[CH2:18][CH2:17]1)[CH3:27]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 57438788HCID 57438788, compound

Product 1

HCID 11630692HCID 11630692, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 8: 4-[2-fluoro-3-(trifluoromethoxy)phenyl]piperidine (0.70 g, 2.66 mmol), acetonitrile (4 ml), potassium carbonate (0.92 g, 6.65 mmol), 1-iodoethane (0.275 ml, 2.93 mmol). Yield: 0.7 g. MS m/z (rel. intensity, 70 eV) 291 (M+, 14), 290 (10), 277 (15), 276 (bp), 193 (8).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-6da9c761e25845dba38514f5e9256eb7
Source dataset
uspto-grants-2010_12
Patent number
US07851629B2

Reaction notes

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