Acetic Anhydride → HCID 46224840, compound

HRID 2264886Notes

Reaction equation

HRID 2264886 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=3)[NH:8][CH2:7][CH2:6][C:5]2=1.CCN(CC)CC.[C:29](OC(=O)C)(=[O:31])[CH3:30]>C1COCC1>[C:29]([N:8]1[CH2:7][CH2:6][C:5]2[C:4]3[C:12](=[CH:13][CH:14]=[C:2]([CH3:1])[CH:3]=3)[NH:11][C:10]=2[CH:9]1[C:15]1[CH:16]=[C:17]([OH:21])[CH:18]=[CH:19][CH:20]=1)(=[O:31])[CH3:30]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 59597173HCID 59597173, compound

Product 1

HCID 46224840HCID 46224840, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-methyl-1-(3-hydroxyphenyl)-1,2,3,4-tetrahydro-beta-carboline (1 equiv) in THF was added Et3N (2.2 equiv) and acetic anhydride (1.2 equiv). After one hour, the solution was purified by prep-HPLC to give 3-(2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)phenol 1.

Workup

  1. customthe solution was purified by prep-HPLC

Sources & evidence

ORD record
ord-9a6a9963720944cf988097d9be83bf1d
Source dataset
uspto-grants-2010_12
Patent number
US07855295B2

Reaction notes

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