反应详情

温度

55 °C

A mixture of 3-(2-fluoro-4-iodo-phenylamino)-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester (210 mg, 0.49 mmol), potassium carbonate (82 mg, 0.59 mmol) and ethyl iodide (44 μl, 0.54 mmol) in DMF was heated at 55° C. for 2 hours. The mixture was allowed to cool to ambient temperature then evaporated. The residue was partitioned between EtOAc (50 mL) and water (15 mL). The organic phase was separated, dried (Na2SO4), filtered and evaporated to give an oil. The oil was purified by flash column chromatography on silica (Si-PPC, pentane:EtOAc, gradient 100:0 to 40:60) to provide the title compound as a yellow solid (80 mg, 36%). LCMS (method B): RT=2.52 min, M+H+=454.

1. temperatureto cool to ambient temperature
2. customthen evaporated
3. customThe residue was partitioned between EtOAc (50 mL) and water (15 mL)
4. customThe organic phase was separated
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. customevaporated
8. customto give an oil
9. customThe oil was purified by flash column chromatography on silica (Si-PPC, pentane:EtOAc, gradient 100:0 to 40:60)