Phenylhydrazine → HCID 178515199, compound

HRID 2265832Notes

Reaction equation

HRID 2265832 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[N:13][C:12]([F:17])=[CH:11][CH:10]=2)=[O:5])C.[C:18]1([NH:24][NH2:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(N(CC)CC)C>[F:17][C:12]1[CH:11]=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:4](=[O:5])[N:24]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[N:25]=[C:15]3[C:14]=2[N:13]=1

Participants

4

Reactant 2

HCID 7516PhenylhydrazineHCID 59597487HCID 59597487, compound

Product 1

HCID 178515199HCID 178515199, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
135 °C

Procedure

In a vial were added 4a, phenyl hydrazine and triethylamine. The vial was sealed and heated to 135° C. for 12 hours. The product was collected by filtration and was washed with methanol in 85% yield. 1H-NMR (DMSO-d6) δ (ppm): 7.18 (1H, dd, J=7.41, 7.14 Hz), 7.50 (3H, m), 8.26 (3H, m), 8.81 (1H, s). m/z 281.3 (MH+).

Workup

  1. customThe vial was sealed
  2. filtrationThe product was collected by filtration
  3. washwas washed with methanol in 85% yield

Sources & evidence

ORD record
ord-2095792d6d01423d8e2285f3643f32e6
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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