Methyl iodide → 2-(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-4-methoxy-but-2-enenitrile

HRID 2266088노트

반응식

HRID 2266088 반응식
[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:6][C:5]=1[O:15][CH2:16][C:17]#[N:18])([CH3:3])[CH3:2].[H-].[Na+].CI>>[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:6][C:5]=1[O:15][C:16](=[CH:4][CH2:5][O:15][CH3:16])[C:17]#[N:18])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 59598566(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-acetonitrile

생성물 1

HCID 670534062-(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-4-methoxy-but-2-enenitrile

실험 절차

2-(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-4-methoxy-but-2-enenitrile was prepared from (6-isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-acetonitrile by treatment with sodium hydride and methyl iodide using the procedure of step 6 of Example 2 above.

출처 및 근거

ORD 기록
ord-aae4b7be19524ad3aeabda7e8d679f17
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858632B2

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