反应详情

A mixture of 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol (0.24 g), N,N-dimethylformamide (2.0 mL), potassium carbonate (0.12 g) and bromoacetic acid methyl ester (0.12 mL) was stirred at room temperature for 17 hours. The mixture was filtered and the filtrate concentrated under reduced pressure. The residue was triturated with diethyl ether and further purification by column chromatography on silica gel, eluting with a mixture of methyl tert-butyl ether and dichloromethane (1:4 to 3:7 by volume) gave title compound, 0.078 g.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. customThe residue was triturated with diethyl ether and further purification by column chromatography on silica gel
4. washeluting with a mixture of methyl tert-butyl ether and dichloromethane (1:4 to 3:7 by volume)