反应详情

2.90 g (13.27 mmol) sodium triacetoxyborohydride were added batchwise to a mixture of 2.58 g (11.06 mmol) benzyl 4-oxo-piperidine-1-carboxylate and 2.80 g (12.36 mmol) tert-butyl (piperidin-4-yloxy)-acetate in 30 mL THF and the reaction mixture was stirred overnight at RT. It was combined with 50 mL 1 M NaOH, the mixture was stirred for 1 h at RT, combined with EtOAc, the organic phase was separated off and dried over Na2SO4. After elimination of the desiccant and solvent the residue was purified by chromatography (Alox, DCM/MeOH 100:1).

1. stirringthe mixture was stirred for 1 h at RT
2. customthe organic phase was separated off
3. dry with materialdried over Na2SO4
4. customAfter elimination of the desiccant and solvent the residue was purified by chromatography (Alox, DCM/MeOH 100:1)