Sodium Iodide → HCID 11663514, compound

HRID 2267556Notes

Reaction equation

HRID 2267556 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[C:18]([C:29]([NH2:31])=[O:30])[CH:19]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)(=[O:7])=[O:6].[CH2:32]([OH:37])[CH2:33][CH2:34][CH2:35][OH:36].C([O-])([O-])=O.[K+].[K+].[I-].[Na+]>>[OH:36][CH2:35][CH2:34][CH2:33][CH2:32][O:37][CH2:2][CH2:3][CH2:4][S:5]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[C:18]([C:29]([NH2:31])=[O:30])[CH:19]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)(=[O:7])=[O:6]

Participants

5

Reactant 4

HCID 5238Sodium IodideHCID 80641,4-ButanediolHCID 11430Potassium CarbonateHCID 590032803-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide

Product 1

HCID 11663514HCID 11663514, compoundYield 20.4%

Procedure

Following the general procedure of example 159, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (40.0 mg, 0.087 mmol), 1,4-butanediol (90 mg, 0.87 mmol), K2CO3 (35.0 mg, 0.35 mmol) and sodium iodide (0.5 mg) were reacted to give the title compound (9.1 mg, 20.4%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3cceff9f43054a0190804bb1ac623b10
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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