Tetrahydrofuran → Isobutyryl chloride

HRID 2268847Notes

Reaction equation

HRID 2268847 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:21])[C:7]=1[CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[CH2:12][NH:11][N:10]=1.[CH2:22](N(CC)CC)C.[CH2:29]1C[O:32][CH2:31][CH2:30]1>>[C:2]([Cl:1])(=[O:32])[CH:7]([CH3:8])[CH3:6].[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:21])[C:7]=1[CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[CH2:12][N:11]([C:31](=[O:32])[CH:30]([CH3:29])[CH3:22])[N:10]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 9797215Phthalazine, 4-[(3,5-dichloro-4-pyridinyl)methyl]-1,2-dihydro-7-methoxy-

Product 2

HCID 62325Isobutyryl chlorideHCID 9843466HCID 9843466, compound

Procedure

Operating substantially as described in example 25 starting from 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-1,2-dihydro-phthalazine (1 g, 3.1 mmoles), prepared as described in example 22, in dry THF (35 ml), triethylamine (1.08 ml, 7.76 mmoles) and isobutanoyl chloride (0.39 ml, 3.72 mmoles), 1 g of the title compound was obtained (yield: 83%). m.p.: 210-212° C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-044b7eef39ed4c7683d18aacea9098dd
Source dataset
uspto-grants-2001_12
Patent number
US06329370B1

Reaction notes

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