反应详情

6-Amino-2-chloropurine (5.02 g) and potassium carbonate (5 g, 36 mmol) were suspended in DMF (200 ml) and thereto was added 4-fluorobenzyl chloride (5 ml, 42 mmol). The mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated in vacuo to dryness, and to the residue was added water. The mixture was extracted with chloroform and the organic layer was washed with water, dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (162 g).

1. concentrationThe reaction mixture was concentrated in vacuo to dryness
2. additionto the residue was added water
3. extractionThe mixture was extracted with chloroform
4. washthe organic layer was washed with water
5. customdried on sodium sulfate
6. concentrationconcentrated in vacuo to dryness
7. customThe residue was purified with silica gel chromatography (2% methanol/chloroform)