Hydrogen Bromide → HCID 18347150, compound

HRID 2269301Notes

Reaction equation

HRID 2269301 reaction equation
CC1C=C2C(=CC=1C)C(=O)CC2.[Br:13]C1CC2C(=CC(C)=C(C)C=2)C1=O.C(N)(=S)C.Br.[CH3:31][C:32]1[S:33][CH:34]2[CH2:43][C:42]3[CH:41]=[C:40]([CH3:44])[C:39]([CH3:45])=[CH:38][C:37]=3[C:35]2(O)[N:36]=1>CC(C)=O.C(O)(=O)C>[BrH:13].[CH3:31][C:32]1[S:33][C:34]2[CH2:43][C:42]3[CH:41]=[C:40]([CH3:44])[C:39]([CH3:45])=[CH:38][C:37]=3[C:35]=2[N:36]=1

Participants

8

Reactant 5

HCID 260Hydrogen BromideHCID 278785,6-Dimethyl-1-indanoneHCID 2723949ThioacetamideHCID 18347144HCID 18347144, compoundHCID 18347158HCID 18347158, compound

Product 1

HCID 18347150HCID 18347150, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 180AcetoneSolvent

Procedure

5,6-Dimethylindan-1-one is converted as described above for the other indan-1-ones into 2-bromo-5,6-dimethylindan-1-one. This is reacted with an equivalent amount of thioacetamide in acetone. The precipitate consisting of the hydrobromide of 2,5,6-trimethyl-8,8a-dihydroindeno-[1,2-d]thiazol-3a-ol is heated in glacial acetic acid and affords, after removal of the solvent and treatment with diisopropyl ether, 2,5,6-trimethyl-8H-indeno[1,2-d]thiazole hydrobromide with a melting point of 290° C.

Workup

  1. customaffords
  2. customafter removal of the solvent and treatment with diisopropyl ether, 2,5,6-trimethyl-8H-indeno[1,2-d]thiazole hydrobromide with a melting point of 290° C.

Sources & evidence

ORD record
ord-8cd861f72bd4437a984e41443941b751
Source dataset
uspto-grants-2001_12
Patent number
US06329407B1

Reaction notes

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