Triethylamine → HCID 18334129, compound

HRID 2269440Notes

Reaction equation

HRID 2269440 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])=O)=[CH:5][CH:4]=1.Cl.[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH2:33])[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH:33][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 18347113Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1)HCID 701880992-Methoxy-5-nitrophenyl 4-methoxyphenyl ketone

Product 1

HCID 18334129HCID 18334129, compound

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 176Acetic AcidSolvent

Procedure

Following a similar procedure to that described in Example (1a), 2.02 of 2-methoxy-5-nitrophenyl 4-methoxyphenyl ketone, 2.02 a of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 4,37 ml of triethylamine, 0.69 ml of titanium tetrachloride, 1.46 g of sodium cyanoborohydride and 0.45 ml of acetic acid were reacted, to obtain 2.10 g of the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-779bf44652df4982a8a90c8e2fdc9b1d
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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