反应详情

WSC (6.5 g) was added to an acetonitrile solution of 7-methoxy-2-oxo-1,2,3,4-tetrahydro-3-quinolinecarboxylic acid (3.74 g), dimethylamine hydrochloride (3.44 g), HOBt (2.85 g) and triethylamine (8.5 g). The reaction mixture was stirred at room temperature for 24 hours and concentrated. The residue was diluted with ethyl acetrate. The organic layer was washed with 1N aqueous hydrochloric acid solution, 10% aqueous potassium carbonate solution, and a saturated aqueous sodium chloride solution, then dried and concentrated. The obtained crude crystals were recrystallized from ethyl acetate-hexane to give the entitled compound (1.63 g).

1. concentrationconcentrated
2. additionThe residue was diluted with ethyl acetrate
3. washThe organic layer was washed with 1N aqueous hydrochloric acid solution, 10% aqueous potassium carbonate solution
4. dry with materiala saturated aqueous sodium chloride solution, then dried
5. concentrationconcentrated
6. customThe obtained crude crystals
7. customwere recrystallized from ethyl acetate-hexane