Triethylamine → HCID 22632938, compound

HRID 2270179Notes

Reaction equation

HRID 2270179 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:13][O:14][C:15]1[CH:32]=[CH:31][C:18]([NH:19][C:20]2[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:21]=2[C:22]([OH:24])=O)=[CH:17][CH:16]=1.Cl.[CH2:34]([O:41][NH2:42])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.C(N(CC)CC)C>>[CH3:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:20]2[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:21]=2[C:22]([NH:42][O:41][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:24])=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 102312Benzyloxyamine hydrochlorideHCID 22632869HCID 22632869, compound

Product 1

HCID 22632938HCID 22632938, compoundYield 102%

Procedure

Using General Method 2, the reaction of carbonyldiimidazole (3.6 g, 22.4 mmol), 2-(4methoxy-anilino)-4,5-difluorobenzoic acid (Example O, 5.72 g, 20.4 mmol), O-benzylhydroxylamine hydrochloride (3.26 g, 20.4 mmol), and triethylamine (3.1 mL, 22.4 mmol) provided 8.0 g of the crude title compound.

Sources & evidence

ORD record
ord-d68e684ff5b7495b86dd57ee38f9d2b6
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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