Diphenyl Ether → 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one
Reaction equation
CO[C:3](=[O:20])[C:4]([C:9](=[O:19])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([F:18])[CH:11]=1)=[CH:5]OCC.[NH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.[C:28]1(OC2C=CC=CC=2)C=CC=CC=1>>[F:18][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][C:13]=1[O:16][CH3:17])[C:9]([C:4]1[C:3](=[O:20])[C:23]2[C:22](=[CH:27][CH:26]=[C:25]([CH3:28])[N:24]=2)[NH:21][CH:5]=1)=[O:19]Participants
4
Procedure
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.70 g (2.61 mmol) of 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl)acrylic acid methyl ester, 0.25 g (2.61 mmol) of 3-aminopyridine, and 15 mL of diphenyl ether to yield 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
Sources & evidence
- ORD record
- ord-65b06b8321f947f7bc0c6e336ed63eef
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07557213B2
Reaction notes
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