Triethylamine → HCID 22632876, compound

HRID 2270210Notes

Reaction equation

HRID 2270210 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([O-:10])=[O:9])=[CH:6][C:5]([F:11])=[C:4](Cl)[N:3]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[CH2:20](N(CC)CC)[CH3:21]>C(#N)C>[Cl:1][C:2]1[C:7]([C:8]([O:10][CH2:20][CH3:21])=[O:9])=[CH:6][C:5]([F:11])=[C:4]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 6951153HCID 6951153, compound

Product 1

HCID 22632876HCID 22632876, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the procedure of Example C-2, the reaction of 2,6-dichloro-5-fluoro-3-pyridinecarboxylate (2.00 g, 8.4 mmol) with 4-methylpiperazine (0.95 mL, 8.4 mmol) in acetonitrile (10 mL) in the presence of triethylamine (1.75 mL, 12.58 mmol) gave 2.34 g of the title compound as an oil.

Sources & evidence

ORD record
ord-61bd12aa9aff4270aceb7f0d5861ba92
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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