反应详情

温度

0 °C

To a solution of 2,6-dimethyl aniline (50 gm) in 1,4-dioxane (400 ml) and N-methylpyrrolidone (40 ml) was added iodine (157.3 gm) slowly at 0° C. The solution was stirred for 1 hour at 0° C. and the temperature was raised to room temperature. The solution was stirred for 1 hour at room temperature and then added a saturated solution of sodium thiosulfate. The layers were separated and the aqueous layer was extracted with methylene chloride. The combined organic layers were dried with anhydrous sodium sulfate and the solvent was evaporated in vacuum to obtain 91 gm of 4-iodo-2,6-dimethyl benzenamine.

1. temperaturethe temperature was raised to room temperature
2. stirringThe solution was stirred for 1 hour at room temperature
3. customThe layers were separated
4. extractionthe aqueous layer was extracted with methylene chloride
5. dry with materialThe combined organic layers were dried with anhydrous sodium sulfate
6. customthe solvent was evaporated in vacuum