反应详情

To a solution of ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate (10.9 mmol) in 150 mL of dichloromethane at 0° C. was added triethylamine (1.53 mL, 10.9 mmol), followed by morpholine (1.34 mL, 15.3 mmol). After 30 minutes, the mixture was poured into ethyl acetate and saturated NaHCO3 solution, and the aqueous phase was extracted three times with ethyl acetate. The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo to give the titled product. ESI+MS: 557.0 [M+H]+.

1. extractionthe aqueous phase was extracted three times with ethyl acetate
2. dry with materialThe combined organic layers were dried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo