Hydrochloric Acid → HCID 68442079, compound

HRID 227476Notes

Reaction equation

HRID 227476 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[C:6]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:5]2[S:25]([N:28]1[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]1)(=[O:27])=[O:26].[ClH:41]>C(OCC)(=O)C>[ClH:41].[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[C:6]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:5]2[S:25]([N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)(=[O:26])=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68444847HCID 68444847, compound

Product 1

HCID 68442079HCID 68442079, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Through a solution of ethyl 5-bromo-3-{[4-(tert-butoxycarbonyl)-piperazin-1-yl]sulfonyl}-1-(phenylsulfonyl)-1H-indole-2-carboxylate (44 mg, 0.067 mmol) in 5 mL of ethyl acetate at 0° C. was bubbled HCl gas for 2 minutes. After stirring an additional 30 minutes, the reaction was concentrated in vacuo to provide the titled product as a white solid. ESI+MS: 556.0 [M+H]+.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-d635bf2d63ec44ae99778e976ce4e379
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

Loading…