反应详情

To an ice-cold suspension of sodium hydride (1.86 mmol, 74 mg) in DMF (1 mL) was added a solution of pyrrole (1.86 mmol, 125 mg) in DMF (2 mL). To this was added 3-fluorosulfonyl-6-methoxypyridazine (1.55 mmol, 298 mg) and the reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched with H2O (20 mL) and EtOAc (20 mL) and the EtOAc layer was collected, dried, filtered and evaporated to a residue. The residue was purified by silica gel chromatography (eluent:hexanes:EtOAc::9:1) to obtain 3-methoxy-6-(pyrrole-1-sulfonyl)-pyridazine (30%, 112 mg).

1. customThe reaction mixture was quenched with H2O (20 mL) and EtOAc (20 mL)
2. customthe EtOAc layer was collected
3. customdried
4. filtrationfiltered
5. customevaporated to a residue
6. customThe residue was purified by silica gel chromatography (eluent:hexanes:EtOAc::9:1)