Potassium Carbonate → HCID 66960277, compound

HRID 2275722Notes

Reaction equation

HRID 2275722 reaction equation
C(O[C:4]([C:6]1C=CC(B(O)O)=C[CH:7]=1)=O)C.NC1CC(C(N(CCC)CCC)=O)=CC2C=CC(Br)=CC=2N=1.COC(C1C=CC(B(O)O)=CC=1)=O.[C:50](=[O:53])([O-])[O-:51].[K+].[K+].[C:56]([O:60][C:61]([NH:63][C:64]1[CH2:65][C:66]([C:86](=[O:102])[N:87]([CH2:91][CH2:92][CH2:93][O:94][Si:95]([C:98]([CH3:101])([CH3:100])[CH3:99])([CH3:97])[CH3:96])[CH2:88][CH2:89][CH3:90])=[CH:67][C:68]2[CH:74]=[CH:73][C:72]([C:75]3[CH:85]=[CH:84][C:78]([C:79]([O:81][CH2:82][CH3:83])=[O:80])=[CH:77][CH:76]=3)=[CH:71][C:69]=2[N:70]=1)=[O:62])([CH3:59])([CH3:58])[CH3:57]>C(#N)C.CCOC(C)=O.ClCCl.C(O)(C(F)(F)F)=O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:63][C:64]1[CH2:65][C:66]([C:86](=[O:102])[N:87]([CH2:91][CH2:92][CH2:93][OH:94])[CH2:88][CH2:89][CH3:90])=[CH:67][C:68]2[CH:74]=[CH:73][C:72]([C:75]3[CH:85]=[CH:84][C:78]([CH2:79][C:50]([O:51][CH:6]([CH3:7])[CH3:4])=[O:53])=[CH:77][CH:76]=3)=[CH:71][C:69]=2[N:70]=1.[C:56]([O:60][C:61]([NH:63][C:64]1[CH2:65][C:66]([C:86](=[O:102])[N:87]([CH2:91][CH2:92][CH2:93][O:94][Si:95]([C:98]([CH3:99])([CH3:101])[CH3:100])([CH3:96])[CH3:97])[CH2:88][CH2:89][CH3:90])=[CH:67][C:68]2[CH:74]=[CH:73][C:72]([C:75]3[CH:85]=[CH:84][C:78]([C:79]([O:81][CH2:82][CH3:83])=[O:80])=[CH:77][CH:76]=3)=[CH:71][C:69]=2[N:70]=1)=[O:62])([CH3:57])([CH3:58])[CH3:59]

Participants

12

Reactant 5

HCID 11430Potassium CarbonateHCID 27343504-Ethoxycarbonylphenylboronic acid2×HCID 27343694-Methoxycarbonylphenylboronic acid2×HCID 66960277HCID 66960277, compoundHCID 66961446(1E,4E)-2-amino-8-bromo-N,N-dipropyl-3H-benzo[b]azepine-4-carboxamide2×

Product 2

HCID 50943697HCID 50943697, compoundYield 42%HCID 66960277HCID 66960277, compoundYield 44%

Reagents, catalysts & solvents 5

HCID 178418397HCID 178418397, compoundCatalystHCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

Isopropyl 2-(4-((1E,4E)-2-amino-4-((3-hydroxypropyl)(propyl)carbamoyl)-3H-benzo[b]azepin-8-yl)phenyl)acetate (42%) was prepared as follows, substituting isopropyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate for 4-(ethoxycarbonyl)phenylboronic acid. Ethyl 4-((1E,4E)-2-(tert-butoxycarbonylamino)-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-3H-benzo[b]azepin-8-yl)benzoate (44%) was prepared as follows, substituting tert-butyl (1E,4E)-8-bromo-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-3H-benzo[b]azepin-2-ylcarbamate for 1E,4E)-2-amino-8-bromo-N,N-dipropyl-3H-benzo[b]azepine-4-carboxamide and 4-(ethoxycarbonyl)phenylboronic acid for 4-(methoxycarbonyl)phenylboronic acid. (1E,4E)-2-amino-8-bromo-N,N-dipropyl-3H-benzo[b]azepine-4-carboxamide (75.0 mgs, 0.206 mmol), 4-(methoxycarbonyl)phenylboronic acid (55.6 mgs, 0.309 mmol, tetrakis(triphenylphosphine)palladium(0) (23.8 mgs, 0.021 mmol), 2M aqueous potassium carbonate (0.309 ml, 0.618 mmol) were combined in 2 mls of acetonitrile in a microwave reaction vial. This mixture was heated in a microwave to 100° C. for 30 minutes. The mixture was then diluted with EtOAc, washed twice with brine, dried over sodium sulfate, and concentrated under reduced pressure. Preparative thin layer chromatography (2×0.5 mm plates, 7% MeOH/DCM) was then used. Ethyl 4-((1E,4E)-2-(tert-butoxycarbonylamino)-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-3H-benzo[b]azepin-8-yl)benzoate (0.050 g, 0.075 mmol) was dissolved in 2 mls of dichloromethane and 0.5 ml of TFA. After about one hour, the mixture was concentrated under reduced pressure and the resulting residue was then re-dissolved in dichloromethane and 1 ml of concentrated ammonium hydroxide added and the mixture vigorously stirred for 15 minutes. This mixture was then diluted with water, extracted with dichloromethane (2×), extracts dried over sodium sulfate and concentrated under reduced pressure. Preparative thin layer chromatography (2×0.5 mm plates, 10% MeOH/DCM/0.5% NH4OH) was used. 1H NMR (400 MHz, CDCl3) δ 7.58-7.64 (m, 2H), 7.48-7.52 (m, 1H), 7.31-7.39 (m, 4H), 6.88 (s, 1H), 5.00-5.08 (m, 1H), 3.58-3.69 (m 6H), 3.44-3.51 (m, 2H), 2.85 (m, 2H), 1.79-1.88 (m, 2H), 1.65-1.75 (m, 2H), 1.23-1.28 (m, 6H), 0.90-0.97 (m, 3H); m/z (APCI-pos) M+1=478.3.

Workup

  1. washwashed twice with brine
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. concentrationthe mixture was concentrated under reduced pressure
  5. dissolutionthe resulting residue was then re-dissolved in dichloromethane
  6. addition1 ml of concentrated ammonium hydroxide added
  7. additionThis mixture was then diluted with water
  8. extractionextracted with dichloromethane (2×)
  9. dry with materialextracts dried over sodium sulfate
  10. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-49e470a4be4445389dcd601caf24dcfd
Source dataset
uspto-grants-2015_09
Patent number
US09126940B2

Reaction notes

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