反应详情

20 g (70.58 mmol) of 12,12-dimethyl-10,12-dihydro-10-azaindeno[2,1-b]-fluorene and 24.6 g (105.87 mmol) of 4-bromobiphenyl are dissolved in toluene and degassed by introduction of a protective gas. 4.94 ml (4.94 mmol, 1 M solution in toluene) of tri-tert-butylphosphine, 633.8 mg (2.82 mmol) of Pd(OAc)2 and 10.2 g (105.87 mmol) of NaOtBu are subsequently added. The solids are degassed in advance, the reaction mixture is subsequently degassed, and then stirred under reflux for 3 h. The warm reaction solution is filtered through Alox B (activity grade 1), washed with water, dried and evaporated. Crystallisation from toluene gives 15.6 g (50.8%) of the product as a white solid having a purity of 99.7%.

1. customdegassed by introduction of a protective gas
2. customThe solids are degassed in advance
3. customthe reaction mixture is subsequently degassed
4. temperatureunder reflux for 3 h
5. customThe warm reaction solution
6. filtrationis filtered through Alox B (activity grade 1)
7. washwashed with water
8. customdried
9. customevaporated
10. customCrystallisation from toluene