Hydrochloric Acid → HCID 49819587, compound

HRID 2276295Notes

Reaction equation

HRID 2276295 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:16][S:17][C:18]1[N:26]=[C:25]2[C:21]([N:22]=[C:23]([CH2:28][CH3:29])[N:24]2[CH3:27])=[C:20]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:19]=1)=[O:11])=O)(C)(C)C.[ClH:41]>O1CCCC1.O1CCOCC1>[ClH:41].[NH2:8][CH2:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:16][S:17][C:18]1[N:26]=[C:25]2[C:21]([N:22]=[C:23]([CH2:28][CH3:29])[N:24]2[CH3:27])=[C:20]([N:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[N:19]=1)=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 49820486HCID 49820486, compound2×

Product 1

HCID 49819587HCID 49819587, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzylsulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine (Compound 62) (140 mg, 0.24 mmol) was dissolved in tetrahydrofuran (15 ml), 4N-hydrogen chloride in dioxane (2 ml) and stirred for 8 hours. After distilling away the solvent under reduced pressure, the residue was washed with ether to obtain 103 mg (83% yield) of Compound 28.

Workup

  1. distillationAfter distilling away the solvent under reduced pressure
  2. washthe residue was washed with ether

Sources & evidence

ORD record
ord-69470714e40c4da0992e4ba41a37a605
Source dataset
uspto-grants-2015_09
Patent number
US09132130B2

Reaction notes

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