Potassium Carbonate → HCID 86725184, compound

HRID 2276357Notes

Reaction equation

HRID 2276357 reaction equation
[OH:1][B:2]1[C@@H:7]([S:8][C:9]2[N:13]([CH3:14])[CH:12]=[N:11][N:10]=2)[CH2:6][C:5]2[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:4]=2[O:3]1.[C:22](=[O:30])([O:26][CH:27]([CH3:29])[CH3:28])[O:23][CH2:24]Cl.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[OH:1][B:2]1[C@@H:7]([S:8][C:9]2[N:13]([CH3:14])[CH:12]=[N:11][N:10]=2)[CH2:6][C:5]2[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([O:21][CH2:24][O:23][C:22]([O:26][CH:27]([CH3:29])[CH3:28])=[O:30])=[O:20])[C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14787051Chloromethyl isopropyl carbonateHCID 86725185HCID 86725185, compound

Product 1

HCID 86725184HCID 86725184, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

To the solution of acid 15 (0.5 mmol) in DMF (5 mL) was added chloromethyl isopropyl carbonate (1 mmol), followed by K2CO3 (0.75 mmol). The resulting mixture was stirred at 50° C. for 18 hours and brought to room temperature and concentrated. The residue was purified by purified by prep-HPLC (C18, acetonitrile and water as mobile phases, 0.1% formic acid) to obtain the titled compound.

Workup

  1. custombrought to room temperature
  2. concentrationconcentrated
  3. customThe residue was purified
  4. customby purified by prep-HPLC (C18, acetonitrile and water as mobile phases, 0.1% formic acid)

Sources & evidence

ORD record
ord-0ea3945baebd4fa585bce254c26bc2a3
Source dataset
uspto-grants-2015_09
Patent number
US09132140B2

Reaction notes

Loading…