Chlorosuccinimide → HCID 86210273, compound

HRID 2276398Notes

Reaction equation

HRID 2276398 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([CH:8]=[N:9][OH:10])=[CH:6][CH:5]=1.[Cl:15]N1C(=O)CCC1=O>CN(C)C=O>[OH:10][N:9]=[C:8]([Cl:15])[C:7]1[CH:11]=[CH:12][C:4]([O:3][C:2]([F:13])([F:14])[F:1])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 2777199p-Trifluoromethoxybenzaldehyde oxime

Product 1

HCID 86210273HCID 86210273, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described in Preparation Example 9, by using dimethylformamide (240 mL), 4-(trifluoromethoxy)benzaldehydeoxime (20.0 g, 97.51 mmol) and N-chlorosuccinimide (14.31 g, 107.26 mmol), a pale yellow solid required compound (21.10 g, 88.04 mmol, 90%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 9

Sources & evidence

ORD record
ord-b2301dcff302406cbc7db282e258aaae
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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