反应详情

A mixture of methyl 6-(cyclopropylmethoxy)-5-fluoronicotinate (1.75 g), THF (15 mL), methanol (1.7 mL) and 2 M aqueous lithium hydroxide solution (7.8 mL) was stirred at room temperature for 20 min. The reaction mixture was neutralized with 1 M hydrochloric acid at 0° C., and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure, and the obtained solid was washed with diethyl ether to give the title compound (1.21 g).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. washthe obtained solid was washed with diethyl ether