Hydrochloric Acid → HCID 86731412, compound

HRID 2277324Notes

Reaction equation

HRID 2277324 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([NH:15]C(=O)OC(C)(C)C)[C:12]([O:23]COC)=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:27]>C1COCC1>[ClH:27].[NH2:15][C:13]1[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:10]=[CH:11][C:12]=1[OH:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86731411HCID 86731411, compound

Product 1

HCID 86731412HCID 86731412, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of tert-butyl (2-(benzyloxy)-5-(methoxymethoxy)pyridin-4-yl)carbamate (11.0 g) in THF (10 mL) and 6 M hydrochloric acid (30 mL) was stirred at 60° C. for 8 hr. The reaction mixture was cooled to 0° C., and the precipitate was collected by filtration, and washed with hexane. The obtained solid was dried under reduced pressure to give the title compound (5.87 g).

Workup

  1. temperatureThe reaction mixture was cooled to 0° C.
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with hexane
  4. customThe obtained solid was dried under reduced pressure

Sources & evidence

ORD record
ord-e0074edd9c0647e8a001863b75ead532
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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