反应详情

15 g (81 mmol) of 4-nitro-1H-imidazole-2-carboxylic acid ethyl ester is stirred under argon together with 13.13 g (97.2 mmol) of cyclopropyl methyl bromide and 22.4 g (162 mmol) of potassium carbonate in 165 ml of DMF for 1 hour at 80° C. After cooling, the reaction mixture is diluted with water and extracted four times with ethyl acetate. The combined organic phases are washed once with water and three times with saturated sodium chloride solution, dried with magnesium sulfate, and concentrated by evaporation in a vacuum. The crystalline residue is immediately reused for the next reaction.

1. temperatureAfter cooling
2. extractionextracted four times with ethyl acetate
3. washThe combined organic phases are washed once with water and three times with saturated sodium chloride solution
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated by evaporation in a vacuum
6. customThe crystalline residue is immediately reused for the next reaction