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A high pressure steel bomb was charged with N-(4-(3-(2-fluoropyridin-4-yl)pyridin-4-yloxy)phenyl)-4-phenylphthalazin-1-amine (0.115 g, 0.237 mmol), potassium carbonate (0.049 g, 0.355 mol) and 3.0 mL of THF. The bomb was sealed, cooled to 0° C. and pressurized with methylamine gas. The reaction mixture was allowed to warm to RT, and heated at 80° C. for 45 h. Upon cooling, the reaction mixture was filtered through a fritted funnel, washed with MeOH, and concentrated. This mixture was purified by silica gel chromatography, (ISCO, 40 g column 0-10% MeOH/dichloromethane) to provide N-(4-(3-(2-(methylamino)pyridin-4-yl)pyridin4-yloxy)phenyl)-4-phenylphthalazin-1-amine as a light yellow solid. MS m/z=497 [M+H]+. Calc'd for C31H24N6O: 496.56.

1. customThe bomb was sealed
2. temperatureto warm to RT
3. temperatureheated at 80° C. for 45 h
4. temperatureUpon cooling
5. filtrationthe reaction mixture was filtered through a fritted funnel
6. washwashed with MeOH
7. concentrationconcentrated
8. customThis mixture was purified by silica gel chromatography, (ISCO, 40 g column 0-10% MeOH/dichloromethane)