反应详情

850 mg of powdered iron are added to a solution of 1.2 g of dimethyl[(E)-2-(2-nitro-6-trifluoromethylphenyl)vinyl]amine in 30 ml of acetic acid. The reaction mixture is refluxed for 16 hours and then poured into a solution of hydrochloric acid (HCl, 2N), and extracted with ethyl acetate. The organic phases are washed with a 10% sodium carbonate solution and then with a saturated NaCl solution, dried over magnesium sulfate, filtered, and concentrated under reduced pressure so as to give 959 mg of 4-trifluoromethyl-1H-indole which is used in the next step.

1. temperatureThe reaction mixture is refluxed for 16 hours
2. extractionextracted with ethyl acetate
3. washThe organic phases are washed with a 10% sodium carbonate solution
4. dry with materialwith a saturated NaCl solution, dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure so as