Lithium Hydroxide → HCID 58449374, compound

HRID 2278748Notes

Reaction equation

HRID 2278748 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][N:13]=2)[CH:11]=1)[C:5]([O:7]C)=[O:6].[OH-].[Li+]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][N:13]=2)[CH:11]=1)[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 59599704Methyl 3-bromo-5-(5-methylpyridin-2-yl)benzoate

Product 1

HCID 58449374HCID 58449374, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A round bottom flask was charged with methyl 3-bromo-5-(5-methylpyridin-2-yl)benzoate (300 mg, 0.98 mmol), tetrahydrofuran (15 mL) and lithium hydroxide (70 mg, 2.94 mmol). The reaction mixture was stirred at 50° C. overnight, and then filtered through sodium sulfate. The filtrate was concentrated under reduced pressure to afford the product as a white solid.

Workup

  1. filtrationfiltered through sodium sulfate
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0a6413ffda344dc0a1ae6d2b7a387569
Source dataset
uspto-grants-2015_09
Patent number
US09133122B2

Reaction notes

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