2-Methoxyethylamine → HCID 90426063, compound

HRID 2278932Notes

Reaction equation

HRID 2278932 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[Cl:6][CH2:7][CH2:8][N:9]=[C:10]=[O:11]>C1COCC1>[Cl:6][CH2:7][CH2:8][NH:9][C:10]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[O:11]

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 160352-Chloroethyl isocyanate

Product 1

HCID 90426063HCID 90426063, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methoxyethylamine (0.40 mL, 4.60 mmol) in THF (15 mL) was treated with 2-chloroethylisocyanate (0.35 mL, 4.10 mmol), stirred at RT for 3 h and concentrated to dryness to afford 1-(2-chloroethyl)-3-(2-methoxyethyl)urea (100% yield assumed) as a white solid. MS (ESI) m/z: 181.1 (M+H+).

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-1a78d46a840746a48e97daebbdf163df
Source dataset
uspto-grants-2015_09
Patent number
US09133183B2

Reaction notes

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