Hydrochloric Acid → HCID 178434387, compound

HRID 2279101Notes

Reaction equation

HRID 2279101 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=3)=[CH:8][C:9]=2[CH2:11][N:12]2[CH2:17][C:16]([CH3:19])([CH3:18])[NH:15][CH2:14][C:13]2([CH3:21])[CH3:20])[N:4](C2CCCCO2)[N:3]=1.Cl>O1CCCC1>[CH3:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:22]3[CH:23]=[CH:24][C:25]([OH:28])=[CH:26][CH:27]=3)=[CH:8][C:9]=2[CH2:11][N:12]2[CH2:17][C:16]([CH3:18])([CH3:19])[NH:15][CH2:14][C:13]2([CH3:21])[CH3:20])[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1366231914-[3-Methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol

Product 1

HCID 178434387HCID 178434387, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

150 mg 4-[3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol were dissolved in 10 ml of tetrahydrofurane and 0.65 ml HCl (4N in 1,4-dioxane) were added. After stirring the reaction at r.t. for 30 min the precipitated residue was isolated by filtration and washed with THF.

Workup

  1. customthe reaction at r.t. for 30 min the precipitated residue
  2. customwas isolated by filtration
  3. washwashed with THF

Sources & evidence

ORD record
ord-c3c0a1e0f5044e3eae258b19f07c7d30
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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