Thioacetamide → Pyrimidine-2-carbothioamide

HRID 2279646Notes

Reaction equation

HRID 2279646 reaction equation
[C:1]([C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].C(N)(=[S:11])C>Cl>[N:4]1[CH:5]=[CH:6][CH:7]=[N:8][C:3]=1[C:1](=[S:11])[NH2:2]

Participants

4

Reactant 2

HCID 2723949ThioacetamideHCID 27579792-Cyanopyrimidine

Product 1

HCID 23273397Pyrimidine-2-carbothioamide

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 2-cyanopyrimidine (15 g) and thioacetamide (20 g) in 100 mL of 10% concentrated HCl in Miff is heated with stirring at 90° C. for three hours and cooled. The solid is collected by filtration, washed with water and dried to afford the title compound.

Workup

  1. temperatureis heated
  2. temperaturecooled
  3. filtrationThe solid is collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-ce581895d9db4aed93601a301b61095a
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

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