Acetic Acid → HCID 86658838, compound

Sodium triacetoxyborohydride (1.22 g, 5.76 mmol) was added to a solution of 4-ethynylbenzaldehyde (0.50 g, 3.84 mmol) in 1,2-dichloroethane (18.75 mL) at rt. Diethylamine (0.61 mL, 5.76 mmol) and acetic acid (0.12 mL, 1.92 mmol) were then added under N2 atmosphere to the mixture at rt and the reaction was stirred for 18 h. The reaction was quenched with sat. sodium bicarbonate solution (10 mL) and the mixture was stirred for 15 min. Dichloromethane (18.75 mL) was then added and the layers were separated. The aqueous layer was extracted using dichloromethane (10 mL), and the combined organic layers were washed with brine and dried over sodium sulfate. The solvent was then removed under vacuum at 40° C./200 mbar. The resultant oily residue was purified by silica gel column chromatography using dichloromethane: methanol (100 to 90:10) gradient to give the title compound as pale yellow thick oil (0.455 g, 63.2%). 1H NMR (400 MHz, CDCl3) δ 7.46 (d, J=8.0 Hz, 2H), 7.76 (d, J=7.6 Hz, 2H), 3.78 (s, 2H), 3.08 (s, 1H), 2.72-2.66 (m, 4H), 1.13 (t, J=7.2 Hz, 6H); MS ESI 187.9 [M+H]+, calcd for [C13H17N+H]+ 187.14.

1. customThe reaction was quenched with sat. sodium bicarbonate solution (10 mL)
2. stirringthe mixture was stirred for 15 min
3. additionDichloromethane (18.75 mL) was then added
4. customthe layers were separated
5. extractionThe aqueous layer was extracted
6. washthe combined organic layers were washed with brine
7. dry with materialdried over sodium sulfate
8. customThe solvent was then removed under vacuum at 40° C./200 mbar
9. customThe resultant oily residue was purified by silica gel column chromatography

ORD record

ord-fd7706a2a6d74cfca536409c47c7206f

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09139563B2