Hydrogen Peroxide → 3-Fluoro-4-(4-formylphenoxy)benzamide

HRID 228186Notes

Reaction equation

HRID 228186 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]#[N:6].OO.C(=O)([O-])[O-:22].[K+].[K+]>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]([NH2:6])=[O:22]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 534256703-Fluoro-4-(4-formylphenoxy)benzonitrile

Product 1

HCID 573525363-Fluoro-4-(4-formylphenoxy)benzamideYield 99%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Hydrolysis of the compound of step 1 using hydrogen peroxide and potassium carbonate in DMSO as described previously afford the above compound in 99% yield.

Workup

  1. customas described previously afford the above compound in 99% yield

Sources & evidence

ORD record
ord-1a96db3b8fc34aa89b4f1710ca0067af
Source dataset
uspto-grants-2009_07
Patent number
US07560463B2

Reaction notes

Loading…