Acetaldehyde → 2-amino-N-benzyl-N-methylacetamide

HRID 2281973Notes

Reaction equation

C(OC([NH:8]CC(O)=O)=O)(C)(C)C.[CH3:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.NC[C@@H]1CCCN1CC.[CH:31](=[O:33])[CH3:32]>>[NH2:8][CH2:32][C:31]([N:14]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:13])=[O:33]

Participants

Reactant 4

HCID 177Acetaldehyde

HCID 7669N-Methylbenzylamine

HCID 78288N-(tert-butoxycarbonyl)glycine

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

Product 1

HCID 179326992-amino-N-benzyl-N-methylacetamide

Procedure

By using N-(t-butoxycarbonyl)glycine (1.0 g) and N-methylbenzylamine (736 μl) as a starting material, the title compound (740 mg) was obtained in the same manners as those of Reference Example 88, (1) and Reference Example 78, (3).

Sources & evidence

ORD record: ord-130aeaeaf18b44ed9daae45a630f7221
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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