反应详情

Using 4-(2-chlorophenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxylic acid (350 mg, 0.94 mmol) produced above, ammonium chloride (3.0 g, 56 mmol), triethylamine (4.5 mL), 1-hydroxybenzotriazole (70 mg, 0.52 mmol), N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (2.0 g, 10 mmol) and N,N-dimethylformamide (50 mL) as starting materials and in the same manner as in Example 13-B(v), the title compound (341 mg, 97%) was obtained as a yellow solid.