Ethanol → HCID 178427650, compound

HRID 2282242Notes

Reaction equation

HRID 2282242 reaction equation
[CH3:1][C:2]1[C:20]([C:21]2[S:22][C:23]([C:32]3[N:36]=[CH:35][NH:34][N:33]=3)=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:25]=2)=[C:5]2[CH:6]=[C:7]([O:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][NH:16][C:15](=[O:19])[CH2:14]3)[CH:8]=[CH:9][N:4]2[N:3]=1.[C:37]1([CH3:47])[CH:42]=[CH:41][C:40]([S:43]([OH:46])(=[O:45])=[O:44])=[CH:39][CH:38]=1.CCO>CCOC(C)=O>[C:37]1([CH3:47])[CH:38]=[CH:39][C:40]([S:43]([OH:46])(=[O:44])=[O:45])=[CH:41][CH:42]=1.[CH3:1][C:2]1[C:20]([C:21]2[S:22][C:23]([C:32]3[N:36]=[CH:35][NH:34][N:33]=3)=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:25]=2)=[C:5]2[CH:6]=[C:7]([O:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][NH:16][C:15](=[O:19])[CH2:14]3)[CH:8]=[CH:9][N:4]2[N:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 178433761HCID 178433761, compound

Product 1

HCID 178427650HCID 178427650, compoundYield 68.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound has been prepared according to the similar manner described in 85-B (iv) from 4-[2-({2-methyl-3-[4-phenyl-5-(1H-1,2,4-triazol-3-yl)-1,3-thiazol-2-yl]pyrazolo[1,5-a]pyridin-5-yl}oxy)ethyl]piperazin-2-one (38.0 mg, 0.0759 mmol) and p-toluenesulfonic acid (31.8 mg, 0.167 mmol). The pure title compound (35 mg, 68%) has been obtained as a pale yellow solid by crystallization from EtOH (8 mL) and EtOAc (2 mL).

Sources & evidence

ORD record
ord-d52cb8b0da2141e7911623ee95bb5769
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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