Hydrochloric Acid → HCID 117875382, compound

HRID 2283419Notes

Reaction equation

HRID 2283419 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11](=[O:35])[CH2:12][C@@H:13]([NH:15][C@@H:16]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:20]=1[F:34])[CH2:17][CH3:18])[CH3:14])(C)(C)C.Cl.C(OCC)C>C(OCC)(=O)C>[NH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:35])[CH2:12][C@H:13]([NH:15][C@@H:16]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:20]=1[F:34])[CH2:17][CH3:18])[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 89544885HCID 89544885, compound

Product 1

HCID 117875382HCID 117875382, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To (2-{(S)-3-[(R)-1-(3-benzoyl-4-chloro-2-fluoro-phenyl)-propylamino]-butyrylamino}-ethyl)-carbamic acid tert-butyl ester (13 mg, 0.025 mmol) residue was added hydrogen chloride in ethyl acetate (2N, 2 ml). The mixture was stood at room temperature for 20 minutes, diethyl ether was added to precipitate solids. These were isolated by filtration and dried in a vacuum oven to furnish the desired material as a white solid

Workup

  1. customto precipitate solids
  2. customThese were isolated by filtration
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-17dc7cc78bb449b6a1ab9e16e04ca547
Source dataset
uspto-grants-2015_09
Patent number
US09145354B2

Reaction notes

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