Hydrochloric Acid → HCID 53713798, compound

HRID 2285825Notes

Reaction equation

HRID 2285825 reaction equation
[Na].[C:2]([O:10]CC)(=O)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([NH:22][CH2:23][CH3:24])[N:15]=1.Cl>O.C(O)C>[CH2:7]([O:6][C:4]([C:3]1[C:2](=[O:10])[N:22]([CH2:23][CH3:24])[C:16]2[C:17]([C:18]=1[NH2:19])=[CH:20][CH:21]=[C:14]([Cl:13])[N:15]=2)=[O:5])[CH3:8]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 5360545SodiumHCID 205246576-Chloro-2-(ethylamino)-3-pyridinecarbonitrile

Product 1

HCID 53713798HCID 53713798, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2.07 g. (0.09 g. atom) of sodium in 75 ml. of ethanol is added 14.4 g. (0.09 mole) of diethyl malonate. The solution is stirred at room temperature for 5 minutes and then 5.4 g. (0.03 mole) of 6-chloro-2-ethylaminonicotinonitrile is added. The mixture is heated under reflux for about 6 hours. The mixture is cooled and diluted with 75 ml. of water and acidified with conc. hydrochloric acid. The precipitate which forms is collected and air dried to give the title compound.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for about 6 hours
  3. temperatureThe mixture is cooled
  4. additiondiluted with 75 ml
  5. customThe precipitate which forms is collected
  6. customair dried

Sources & evidence

ORD record
ord-24d669260d4f4d56817846f247dab9dc
Source dataset
uspto-grants-1982_04
Patent number
US04324893

Reaction notes

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