Hydrochloric Acid → HCID 23459572, compound

HRID 2287209Notes

Reaction equation

HRID 2287209 reaction equation
CNC.C([Li])CCC.CCCCCC.CN(C)P(=O)(N(C)C)N(C)C.[Br:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[C:29]([CH3:35])[CH:28]=1.[C:36]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=1)#[N:37].[ClH:44]>O1CCCC1>[ClH:44].[NH2:32][C:31]1[C:30]2[C:29](=[CH:28][C:27]([Br:26])=[CH:34][CH:33]=2)[CH:35]=[C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[N:37]=1

Participants

9

Reactant 7

HCID 313Hydrochloric Acid3×HCID 674DimethylamineHCID 7522Pyridine-2-carbonitrileHCID 8058HexaneHCID 12679HexamethylphosphoramideHCID 1442674-Bromo-2-methylbenzonitrileHCID 178418339Butyllithium

Product 1

HCID 23459572HCID 23459572, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Conditions

Temperature
-78 °C

Procedure

To a solution of 10.5 g (0.23 mol) of dimethylamine in 80 ml of tetrahydrofuran, 100 ml of 15% (w/v) n-butyl lithium in hexane (0.23 mol) were added under a nitrogen atmosphere. After 30 minutes, 18 g (0.1 mol) of hexamethylphosphoric triamide (HMPTA) were added, after which the mixture was cooled to -78° C. To the light-yellow solution obtained, 19.6 g (0.1 mol) of 4-bromo-2-methylbenzonitrile in 60 ml of anhydrous tetrahydrofuran were added in the course of 10 minutes, after which the deep red solution was stirred for another 15 minutes. Subsequently 15.7 g (0.15 mol) of 2-cyanopyridine in 60 ml of anhydrous tetrahydrofuran was added dropwise in the course of 10 minutes. The reaction mixture was heated to 60° C. for one hour and it was then hydrolysed with 400 ml of 10% (w/v) hydrochloric acid. The yellow precipitate obtained was filtered off, the filtrate was washed with diethyl ether, neutralised with sodium hydroxide and extracted with chloroform. The solvent was distilled off from the extract and the residue was sublimed. The product obtained was converted into the hydrochloride, as described in Example VII, and the hydrochloride was combined with the yellow precipitate and crystallised from ethanol. 1-Amino-6-bromo-3-(2-pyridyl)isoquinoline hydrochloride was obtained, melting point 257.5° C.

Workup

  1. customTo the light-yellow solution obtained
  2. temperatureThe reaction mixture was heated to 60° C. for one hour
  3. customThe yellow precipitate obtained
  4. filtrationwas filtered off
  5. washthe filtrate was washed with diethyl ether
  6. extractionextracted with chloroform
  7. distillationThe solvent was distilled off from the
  8. extractionextract
  9. customThe product obtained
  10. customcrystallised from ethanol

Sources & evidence

ORD record
ord-b82d6aa337644e1e8acb4be57b5a3476
Source dataset
uspto-grants-1981_05
Patent number
US04269834

Reaction notes

Loading…