Hydrochloric Acid → HCID 86584236, compound

HRID 2288204Notes

Reaction equation

HRID 2288204 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][C@@H:6]1[CH2:11][N:10]([CH2:12][CH2:13][OH:14])[CH2:9][CH2:8][N:7]1[C:15](=[O:30])[C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][C@@H:6]1[CH2:11][N:10]([CH2:12][CH2:13][OH:14])[CH2:9][CH2:8][N:7]1[C:15](=[O:30])[C:16]1[CH:17]=[C:18]([C:26]([F:28])([F:27])[F:29])[CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53926082HCID 53926082, compound

Product 1

HCID 86584236HCID 86584236, compoundYield 168.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of (2R)-2-(3,4-dichlorobenzyl)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-(2-hydroxyethyl)piperazine (50 mg) in ethyl acetate (3 ml) was treated with 4N hydrogen chloride in ethyl acetate solution (0.2 ml) and the resulting mixture was concentrated in vacuo to give (2R)-2-(3,4-dichlorobenzyl)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-(2-hydroxyethyl)piperazine hydrochloride (45 mg) as a powder.

Workup

  1. concentrationthe resulting mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-be6cc6b9b63e4b45ba6516140e472fc2
Source dataset
uspto-grants-2000_07
Patent number
US06087357

Reaction notes

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