Hydrochloric Acid → 1-Methyl-1H-pyrazole-4-propanal

To a solution of oxalyl chloride (0.361 ml) in dichloromethane (10 ml) cooled below -65° C. with a dry ice-acetone bath, a solution of dimethyl sulfoxide (0.381 ml) in dichloromethane (1 ml) was added with efficient stirring over 10 minutes. After 20 minutes below -65° C., a solution of 3-(1-methyl-1H-pyrazol-4-yl)-1-propanol in dichloromethane (2 ml) was added to the mixture over 10 minutes below -65° C. and the mixture was stirred at the same temperature for 20 minutes and then at -45~-40° C. for 30 minutes. After addition of triethylamine dropwise to the mixture over 10 minutes followed by stirring for 15 minutes, 1N hydrochloric acid solution was added to the mixture. The resulting mixture was extracted with a mixture of dichloromethane and methanol several times. The extract was concentrated under reduced pressure and the resulting residue was chromatographed on a silica gel using a mixture of dichloromethane and methanol as an eluent to give 3-(1-methyl-1H-pyrazol-4-yl)-1-propanal.

1. waitAfter 20 minutes below -65° C.
2. stirringthe mixture was stirred at the same temperature for 20 minutes
3. waitat -45~-40° C. for 30 minutes
4. stirringby stirring for 15 minutes
5. extractionThe resulting mixture was extracted with a mixture of dichloromethane and methanol several times
6. concentrationThe extract was concentrated under reduced pressure
7. customthe resulting residue was chromatographed on a silica gel using
8. additiona mixture of dichloromethane and methanol as an eluent

ORD record

ord-616633f52b5b42e9933a19d496424a5b

Source dataset

uspto-grants-2000_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06087357