反应详情

In a 250-ml flask are combined 4-(2-chloroethoxy)benzoic acid (2.58 g, 12.9 mmol), dimethylformamide (0.2 ml) and 1,2-dichloroethane (50 ml). Oxalyl chloride (1.35 ml) is added dropwise and the reaction mixture stirred overnight at room temperature. The reaction becomes homogeneous after stirring several hours. After an overnight stir, the solvent is evaporated to dryness, and the solid product is redissolved in 1,2-dichloroethane (2×50 mL) and evaporated. The product is used as is in subsequent reactions.

1. customIn a 250-ml flask are combined
2. stirringafter stirring several hours
3. stirringAfter an overnight stir
4. customthe solvent is evaporated to dryness
5. dissolutionthe solid product is redissolved in 1,2-dichloroethane (2×50 mL)
6. customevaporated