反应详情

温度

70 °C

Cyanoacetylurea (38.7 g) was suspended in N,N-dimethylformamide (77.4 ml), and acetone (24.6 ml), acetic acid (3.43 ml) and ammonium acetate (2.31 g) were added. This suspension was subjected to catalytic hydrogenation in the presence of 10% palladium carbon (0.78 g, 50% wet product) under normal pressure at 30° C. for 9 hours. The reaction mixture was heated to 70° C., and the catalyst was filtered off. Water (150 ml) was added to the filtrate to allow precipitation of crystals. The crystals were collected by filtration to give N-(2-cyano-3-methylbutanoyl)urea (yield 40.1 g).

1. filtrationthe catalyst was filtered off
2. additionWater (150 ml) was added to the filtrate
3. customprecipitation of crystals
4. filtrationThe crystals were collected by filtration