Hydrochloric Acid → HCID 54103739, compound

HRID 2289336Notes

Reaction equation

HRID 2289336 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][N:13]=[N:12]2)[CH:8]=[CH:7][C:6]=1[CH2:16][C:17]([O:19]C)=[O:18].O.O[Li].O.Cl>C1COCC1>[F:22][C:2]([F:1])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][N:13]=[N:12]2)[CH:8]=[CH:7][C:6]=1[CH2:16][C:17]([OH:19])=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54322616HCID 54322616, compound

Product 1

HCID 54103739HCID 54103739, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of methyl 2-(2,2,2-trifluoroethoxy)-4-(1-triazolyl)phenylacetate (0.54 g, 1.7 mmol) from Step 2 above in THF (10 mL) and water (2.5 mL) was added LiOH.H2O (0.11 g, 2.6 mmol). The mixture was stirred at ambient temperature for 14 h. The solution was adjusted to pH 2 by the addition of 5 N aqueous HCl and the solvents were removed under reduced pressure to give 2-(2,2,2-trifluoroethoxy)-4-(1-triazolyl)phenylacetic acid was obtained as a gum (HPLC retention time=6.0 min (method A)).

Workup

  1. customthe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-d134115e4d6c4822ad63832cf58ede1f
Source dataset
uspto-grants-2000_07
Patent number
US06090805

Reaction notes

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