Hydrochloric Acid → HCID 18700162, compound

HRID 2289345Notes

Reaction equation

HRID 2289345 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3([C:26]([N:28]4[CH2:33][CH2:32][CH:31]([N:34]5[C:39]6[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=6[CH2:37][O:36][C:35]5=[O:44])[CH2:30][CH2:29]4)=[O:27])[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:17]([O:45][CH3:46])[CH:16]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.Cl>CCOC(C)=O>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3([C:26]([N:28]4[CH2:29][CH2:30][CH:31]([N:34]5[C:39]6[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=6[CH2:37][O:36][C:35]5=[O:44])[CH2:32][CH2:33]4)=[O:27])[CH2:22][CH2:23][CH2:24][CH2:25]3)=[C:17]([O:45][CH3:46])[CH:16]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18700139HCID 18700139, compound

Product 1

HCID 18700162HCID 18700162, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Into a solution of 1-(1-(1-(4-(N-Boc-4-piperidinyloxy)-2-methoxyphenyl)cyclopentylcarbonyl)-piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one (0.15 g, 0.24 mmol) from Step 9 above in EtOAc (10 mL) at 0° C. was bubbled HCl gas for 10 min. The solution was warmed to ambient temperature and stirred for 1 h. The solvent was removed under reduced pressure to give the title compound as an amorphous solid.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0822ab0261014fa5a23f86245bcc2407
Source dataset
uspto-grants-2000_07
Patent number
US06090805

Reaction notes

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