Hydrochloric Acid → HCID 23078261, compound

HRID 229035Notes

Reaction equation

HRID 229035 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=O)=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:11][C:12](=O)[CH2:13][CH3:14].[OH-:16].[Na+].Cl>>[CH2:13]([C:12]1[C:11]([OH:16])=[CH:8][C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[N:1]=1)[CH3:14]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 131561-Bromo-2-butanoneHCID 14798Sodium HydroxideHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

Product 1

HCID 23078261HCID 23078261, compoundYield 74%

Procedure

2-Amino-pyridine-3-carbaldehyde (100 mg) and 1-bromo-butan-2-one (124 mg) were suspended in a 5 N aqueous sodium hydroxide solution (0.6 ml), and the suspension was hermetically sealed and, in this state, was allowed to stand for 3 days. The reaction solution was neutralized with 10% hydrochloric acid, and the precipitate was then filtered. The residue was washed with water and chloroform. The powder as the residue was dried under the reduced pressure to give 2-ethyl-[1,8]naphthyridin-3-ol (106 mg, yield 74%).

Workup

  1. customthe suspension was hermetically sealed and, in this state
  2. filtrationthe precipitate was then filtered
  3. washThe residue was washed with water and chloroform
  4. customThe powder as the residue was dried under the reduced pressure

Sources & evidence

ORD record
ord-0edd1f8b30e14d7c9ea0066e032efd63
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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