Water → HCID 13386052, compound

HRID 2290738Notes

Reaction equation

HRID 2290738 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]([CH3:18])[NH:13][C:14](=[O:17])[NH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[Cl:19]N1C(=O)CCC1=O.O>CN(C)C=O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]([CH3:18])[NH:13][C:14](=[O:17])[NH:15][N:16]=2)=[CH:9][C:10]=1[Cl:19])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 13386032HCID 13386032, compound

Product 1

HCID 13386052HCID 13386052, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 6-(4-acetamidophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.5 g) and N-chlorosuccinimide (0.41 g) in dimethylformamide (7 ml) was stirred at 40° C. for 3 hours and then poured into water. The thus-produced crsytals were collected by filtration, washed with water and dried to give 6-(4-acetamido-3-chlorophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (0.331 g).

Workup

  1. filtrationThe thus-produced crsytals were collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-6ce85b432652487ea9bc7c760b869448
Source dataset
uspto-grants-1986_10
Patent number
US04618610

Reaction notes

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